解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The microenvironment of glioblastoma (GBM) contains high levels of inflammatory cytokine interleukin 6 (IL-6), which contributes to promote tumour progression and invasion. The common epidermal growth factor receptor variant III (EGFRvIII) mutation in GBM is associated with significantly higher levels of IL-6. Further...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.225
更新日期:2015-05-28 00:00:00
abstract::Tripartite motif 24 protein (TRIM24) is a plant homeodomain/bromodomain histone reader, recently associated with poor overall survival of breast-cancer patients. At a molecular level, TRIM24 is a negative regulator of p53 levels and a co-activator of estrogen receptor. However, the role of TRIM24 in breast tumorigenes...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.220
更新日期:2015-05-28 00:00:00
abstract::Cancer stem cell (CSC), the primary source of cancer-initiating population, is involved in cancer recurrence and drug-resistant phenotypes. This study demonstrates that the loss of DAB2IP, a novel Ras-GTPase activating protein frequently found in many cancer types, is associated with CSC properties. Mechanistically, D...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.215
更新日期:2015-05-21 00:00:00
abstract::Gastric cancer (GC) is one of the most common tumors and the molecular mechanism underlying its metastasis is still largely unclear. Here, we show that miR-25 was overexpressed in plasma and primary tumor tissues of GC patients with tumor node metastasis stage (III or IV) or lymph node metastasis. MiR-25 inhibition si...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.214
更新日期:2015-05-14 00:00:00
abstract::Oncogenic RAS promotes production of reactive oxygen species (ROS), which mediate pro-malignant signaling but can also trigger DNA damage-induced tumor suppression. Thus RAS-driven tumor cells require redox-protective mechanisms to mitigate the damaging aspects of ROS. Here, we show that MutT Homolog 1 (MTH1), the mam...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.195
更新日期:2015-05-14 00:00:00
abstract::Polyoma small T antigen (PyST), an early gene product of the polyoma virus, has been shown to cause cell death in a number of mammalian cells in a protein phosphatase 2A (PP2A)-dependent manner. In the current study, using a cell line featuring regulated expression of PyST, we found that PyST arrests cells in mitosis....
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.192
更新日期:2015-05-07 00:00:00
abstract::Heat shock protein (Hsp)90 regulates many key pathways in oncogenesis, including Akt and mammalian target of rapamycin (mTOR). The strengths of disruption of Hsp90 in cancer therapy include their versatility in inhibiting a wide range of oncogenic pathways. The present study demonstrated that synuclein γ (SNCG) protec...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.126
更新日期:2015-04-30 00:00:00
abstract::The molecular basis for the resistance of tumor cells to cell-mediated cytotoxicity remains poorly understood and thus poses a major challenge for cancer immunotherapy. The present study was designed to determine whether the WNT1-inducible signaling pathway protein 2 (WISP2, also referred to as CCN5), a key regulator ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.151
更新日期:2015-04-23 00:00:00
abstract::Somatic alterations of fibroblast growth factor receptors (FGFRs) have been described in a wide range of malignancies. A number of anti-FGFR therapies are currently under investigation in clinical trials for subjects with FGFR gene amplifications, mutations and translocations. Here, we develop cell line models of acqu...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.161
更新日期:2015-04-23 00:00:00
abstract::Leukemic lymphoblasts within different immunophenotypic populations possess stem cell properties. However, whether or not the self-renewal program is retained from stem cells or conferred on progenitors by leukemogenic molecules remains unknown. We have addressed the issue in the context of TEL-AML1-associated acute l...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.148
更新日期:2015-04-16 00:00:00
abstract::Lysyl oxidase (LOX) is a multifunctional protein required for normal collagen and elastin biosynthesis and maturation. In addition, LOX has complex roles in cancer in which the lysyl oxidase propeptide (LOX-PP) domain of secreted pro-LOX has tumor-suppressor activity, while the active enzyme promotes metastasis. In pr...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.147
更新日期:2015-04-09 00:00:00
abstract::Only humans and higher primates have high uric acid blood levels. Although high uric acid causes gout, it has been linked with human longevity because of its hypothetical antioxidant function. Recent studies reveal that p53 has significant roles in cellular metabolism. One example of this is an antioxidant function th...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.119
更新日期:2015-04-02 00:00:00
abstract::Talins are adaptor proteins that regulate focal adhesion signaling by conjugating integrins to the cytoskeleton. Talins directly bind integrins and are essential for integrin activation. We previously showed that β1 integrins are activated in metastatic prostate cancer (PCa) cells, increasing PCa metastasis to lymph n...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.116
更新日期:2015-04-02 00:00:00
abstract::Ubiquilin1 (UBQLN1) is a ubiquitin-like domain and a ubiquitin-associated domain containing protein that has been reported to be involved in shuttling proteins to the proteasome, especially during endoplasmic reticulum-associated protein degradation. Thus, UBQLN1 function has been shown to be critical for combating a ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.97
更新日期:2015-03-26 00:00:00
abstract::Emerging evidence has shown that cancer stem cells (CSCs) are the cellular determinants to promote cancer invasion and metastasis. However, the mechanism underlying CSC invasion remains unknown. MicroRNAs are evolutionally conserved small noncoding RNAs that are critical for the regulation of gene expression, and thei...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.75
更新日期:2015-03-12 00:00:00
abstract::The tumor suppressor gene Pdcd4 (programmed cell death gene 4) has drawn considerable attention because its downregulation is involved in the development of several types of cancer. Because Pdcd4 interacts with the translation initiation factor eIF4A and inhibits its helicase activity, Pdcd4 has been implicated in the...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.83
更新日期:2015-03-12 00:00:00
abstract::Hec1 (highly expressed in cancer 1) or Nek2 (NIMA-related kinase 2) is often overexpressed in cancers with poor prognosis. Both are critical mitotic regulators, and phosphorylation of Hec1 S165 by Nek2 is required for proper chromosome segregation. Therefore, inactivation of Hec1 and Nek2 by targeting their interactio...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.67
更新日期:2015-03-05 00:00:00
abstract::Protein kinase A (PKA) hyperactivation causes hereditary endocrine neoplasias; however, its role in sporadic epithelial cancers is unknown. Here, we show that heightened PKA activity in the mammary epithelium generates tumors. Mammary-restricted biallelic ablation of Prkar1a, which encodes for the critical type-I PKA ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.41
更新日期:2015-02-26 00:00:00
abstract::Recent studies suggest that medulloblastoma, the most common malignant brain tumor of childhood, is comprised of four disease variants. The WIP1 oncogene is overexpressed in Group 3 and 4 tumors, which contain medulloblastomas with the most aggressive clinical behavior. Our data demonstrate increased WIP1 expression i...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.37
更新日期:2015-02-26 00:00:00
abstract::Epithelial-to-mesenchymal transition (EMT) promotes cell motility, which is important for the metastasis of malignant cells, and blocks CD95-mediated apoptotic signaling triggered by immune cells and chemotherapeutic regimens. CD95L, the cognate ligand of CD95, can be cleaved by metalloproteases and released as a solu...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.55
更新日期:2015-02-19 00:00:00
abstract::Polymorphisms and somatic mutations in Flap Endonuclease 1 (FEN1), an essential enzyme involved in DNA replication and repair, can lead to functional deficiencies of the FEN1 protein and a predisposition to cancer. We identified a FEN1 germline mutation that changed residue E359 to K in a patient whose family had a hi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.19
更新日期:2015-02-12 00:00:00
abstract::Metastatic growth in breast cancer (BC) has been proposed as an exclusive property of cancer stem cells (CSCs). However, formal proof of their identity as cells of origin of recurrences at distant sites and the molecular events that may contribute to tumor cell dissemination and metastasis development are yet to be el...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.5
更新日期:2015-02-05 00:00:00
abstract::Several common biological properties between cancer cells and embryonic stem (ES) cells suggest the possibility that some genes expressed in ES cells might have important roles in cancer cell growth. The transcription factor ZFP57 is expressed in self-renewing ES cells and its expression level decreases during ES cell...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.599
更新日期:2015-02-05 00:00:00
abstract::The maintenance cytosine DNA methyltransferase DNMT1 and de novo methyltransferase DNMT3b cooperate to establish aberrant DNA methylation and chromatin complexes to repress gene transcription during cancer development. The expression of DNMT3b was constitutively increased 5-20-fold in hTERT/CDK4-immortalized human bro...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.580
更新日期:2015-01-29 00:00:00
abstract::Many of the current antitumor therapeutic strategies are based on the perturbation of the cell cycle, especially during mitosis. Antimitotic drugs trigger mitotic checkpoint activation, mitotic arrest and eventually cell death. However, mitotic slippage represents a major mechanism of resistance to these treatments. I...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.601
更新日期:2015-01-29 00:00:00
abstract::EZH2 (enhancer of zeste homolog 2) is a critical enzymatic subunit of the polycomb repressive complex 2 (PRC2), which trimethylates histone H3 (H3K27) to mediate gene repression. Somatic mutations, overexpression and hyperactivation of EZH2 have been implicated in the pathogenesis of several forms of cancer. In partic...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.571
更新日期:2015-01-22 00:00:00
abstract::Aromatase inhibitors (AIs) are the standard endocrine therapy for postmenopausal breast cancer; however, currently used biomarkers, such as, estrogen receptor-alpha/progesterone receptor (ERα/PR), predict only slightly more than half of the potential responders to AI treatment. To identify novel markers of AI responsi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.553
更新日期:2015-01-15 00:00:00
abstract::Rac1-GTPases serve as intermediary cellular switches, which conduct transient and constitutive signals from upstream cues, including those from Ras oncoproteins. Although the sirtuin1 (SIRT1) deacetylase is overexpressed in several human cancers and has recently been linked to cancer cell motility as a context-depende...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.549
更新日期:2015-01-08 00:00:00
abstract::Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine with the capability to act as tumour suppressor or tumour promoter depending on the cellular context. TGF-beta receptor type-2 (TGFBR2) is the ligand-binding receptor for all members of the TGF-β family. Data from mouse model experiments demonstrated th...
journal_title:Oncogene
pub_type: 杂志文章,随机对照试验
doi:10.1038/onc.2013.527
更新日期:2015-01-02 00:00:00
abstract::Alternative splicing has critical roles in normal development and can promote growth and survival in cancer. Aberrant splicing, the production of noncanonical and cancer-specific mRNA transcripts, can lead to loss-of-function in tumor suppressors or activation of oncogenes and cancer pathways. Emerging data suggest th...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2013.570
更新日期:2015-01-02 00:00:00
abstract::Castration-resistant prostate cancer (CRPC) continues to pose a significant clinical challenge with new generation second-line hormonal therapies affording limited improvement in disease outcome. As the androgen receptor (AR) remains a critical driver in CRPC, understanding the determinants of its transcriptional acti...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.508
更新日期:2014-12-11 00:00:00
abstract::The discovery of constitutive nuclear factor-κB (NF-κB) activation in Hodgkin's lymphoma tumor cells almost two decades ago was one of the first reports that directly connected deregulated NF-κB signaling to human cancer. Subsequent studies demonstrated that enhanced NF-κB signaling is a common hallmark of many lympho...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2013.565
更新日期:2014-12-11 00:00:00
abstract::Lineage-restricted transcription factors (TFs) are frequently mutated or overexpressed in cancer and contribute toward malignant behaviors; however, the molecular bases of their oncogenic properties are largely unknown. As TF activities are difficult to inhibit directly with small molecules, the genes and pathways the...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.517
更新日期:2014-12-04 00:00:00
abstract::SALL4, a zinc-finger transcriptional factor for embryonic stem cell self-renewal and pluripotency, has been suggested to be involved in tumorigenesis. The role of SALL4 in human gastric cancer, however, remains largely unknown. In this study, we demonstrated that SALL4 was aberrantly expressed at both mRNA and protein...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.495
更新日期:2014-11-27 00:00:00
abstract::RAS-driven malignancies remain a major therapeutic challenge. The two-stage 7,12-dimethylbenz(a)anthracene (DMBA)/12-o-tetradecanoylphorbol-13-acetate (TPA) model of mouse skin carcinogenesis has been used to study mechanisms of epithelial tumor development by oncogenic Hras. We used mice with an Hras(G12V) knock-in a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.489
更新日期:2014-11-20 00:00:00
abstract::We show that expression of the microtubule depolymerizing kinesin KIF2C is induced by transformation of immortalized human bronchial epithelial cells (HBEC) by expression of K-Ras(G12V) and knockdown of p53. Further investigation demonstrates that this is due to the K-Ras/ERK1/2 MAPK pathway, as loss of p53 had little...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.486
更新日期:2014-11-20 00:00:00
abstract::SAG (Sensitive to Apoptosis Gene), also known as RBX2 or ROC2, is a RING protein required for the activity of Cullin-RING ligase (CRL). Our recent study showed that Sag total knockout caused embryonic lethality at E11.5-12.5 days with associated defects in vasculogenesis. Whether Sag is required for de novo vasculogen...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.473
更新日期:2014-10-30 00:00:00
abstract::To elucidate the mechanisms behind the high sensitivity of myxoid/round cell liposarcoma (MRCL) to trabectedin and the suggested selectivity for specific subtypes, we have developed and characterized three MRCL xenografts, namely ML017, ML015 and ML004 differing for the break point of the fusion gene FUS-CHOP, respect...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.462
更新日期:2014-10-30 00:00:00
abstract::Cytosolic proteins containing SH2 and SH3 domains, such as Crk and Crk-like (CrkL), are broadly expressed adapters that interact with a variety of proteins to fulfill key roles in signal transduction pathways triggered by activation of receptor and non-receptor tyrosine kinases. Crk and CrkL are similar to each other ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.453
更新日期:2014-10-23 00:00:00
abstract::Mesenchymal stem cells (MSCs) are a kind of adult stem cells that can be isolated easily from bone marrow, adipose tissue, umbilical cord and many other tissues. MSCs have been shown to specifically migrate to inflammatory sites, including tumors, and hold great promise as tumor-specific vectors to deliver antitumor a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.458
更新日期:2014-10-16 00:00:00